Modern medicine treats neurodegenerative diseases (NDs) as a collection of symptoms. We see them as a single, recursive failure.
Our central thesis is that Lysosomal Dysfunction is not merely a consequence, but the invariant root cause that initiates and sustains the pathological loop.
This is a closed loop. Inflammation drives further lysosomal stress, which drives further mitochondrial failure. Current drugs target the branches. Isoradix targets the root.
We are building the computational and biological frameworks to prove this connection and intervene.
We do not aim to manage the decline. We aim to decouple the loop. By restoring lysosomal acidity and function, we hypothesize that the downstream cascades—mitochondrial failure and inflammation—will auto-correct.
Biology is hardware. We debug it in-silico first.
We utilize high-fidelity Computer-Aided Drug Design (CADD) pipelines to simulate the lysosomal environment at atomic resolution. We don't just look for binding affinity; we model for pH-dependent stability.
By filtering millions of molecular candidates computationally, we identify the few invariant structures capable of penetrating the blood-brain barrier and restoring enzymatic function at pH 4.5. We simulate the cure before we synthesize it.
This is a multi-decade problem requiring a specific type of mind. We are looking for the few who are obsessed with the root cause rather than the convenient consensus.
IF YOU SEE THE LOOP, HELP US BREAK IT.
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